A recent publication reveals progressive, dose-dependent ventricular enlargement in the brains of patients with early Alzheimer disease who were treated with the FDA-approved drug aducanumab. Aducanumab joins a growing list of anti-amyloid-β therapies for which there is evidence that they cause accelerated neurodegeneration; extended follow-up studies are required to determine whether aducanumab causes progressive brain damage.

中文翻译：

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aducanumab 引起的心室扩大

最近的一份出版物揭示了接受 FDA 批准的药物 aducanumab 治疗的早期阿尔茨海默病患者大脑中进行性、剂量依赖性的脑室扩大。Aducanumab 加入了越来越多的抗淀粉样蛋白-β 疗法，有证据表明它们会加速神经退行性变；需要进一步的后续研究来确定 aducanumab 是否会导致进行性脑损伤。