Abstract

Objective: Our aim was to assess mean platelet volume (MPV) and mean platelet volume to platelet count ratio (MPR) in the setting of late-onset sepsis (LOS) and their association with the type of bacteria causing LOS. Study design: The MPV and MPR levels were obtained at the onset of LOS and then assessed in intra/inter group analyses in preterm infants. Results: Overall, 136 preterm infants were enrolled. The MPV and MPR levels were higher during a LOS event (P < 0.001). A MPV cutoff of >9.2 was related with a sensitivity of 63% and a specificity of 73% for predicting LOS (P < 0.001). A MPR cutoff of >0.15 was related with a sensitivity of 88% and a specificity of 63% for predicting gram negative LOS (P < 0.001). Conclusion: Elevated MPV values and MPR ratios may be helpful in assessing LOS.

摘要

目的：我们的目的是评估迟发性败血症 (LOS) 情况下的平均血小板体积 (MPV) 和平均血小板体积与血小板计数比 (MPR) 及其与导致 LOS 的细菌类型的关系。研究设计：在 LOS 开始时获得 MPV 和 MPR 水平，然后在早产儿的组内/组间分析中进行评估。结果：总共有 136 名早产儿入组。MPV 和 MPR 水平在 LOS 事件期间较高 ( P  < 0.001)。MPV 截断 >9.2 与预测 LOS 的灵敏度为 63% 和特异性为 73% 相关 ( P  < 0.001)。>0.15 的 MPR 截断值与预测革兰氏阴性 LOS 的灵敏度为 88% 和特异性为 63% 相关（P < 0.001)。结论：升高的 MPV 值和 MPR 比率可能有助于评估 LOS。