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Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio Are Predictors of Late-Onset Sepsis in Preterm Infants: A Case-Control Study
Fetal and Pediatric Pathology ( IF 0.7 ) Pub Date : 2022-04-19 , DOI: 10.1080/15513815.2022.2064574
Ipek Guney Varal 1 , Pelin Dogan 1 , Ezgi Acar Celik 2 , Elif Güler Kazancı 3
Affiliation  

Abstract

Objective: Our aim was to assess mean platelet volume (MPV) and mean platelet volume to platelet count ratio (MPR) in the setting of late-onset sepsis (LOS) and their association with the type of bacteria causing LOS. Study design: The MPV and MPR levels were obtained at the onset of LOS and then assessed in intra/inter group analyses in preterm infants. Results: Overall, 136 preterm infants were enrolled. The MPV and MPR levels were higher during a LOS event (P < 0.001). A MPV cutoff of >9.2 was related with a sensitivity of 63% and a specificity of 73% for predicting LOS (P < 0.001). A MPR cutoff of >0.15 was related with a sensitivity of 88% and a specificity of 63% for predicting gram negative LOS (P < 0.001). Conclusion: Elevated MPV values and MPR ratios may be helpful in assessing LOS.



中文翻译:

平均血小板体积和平均血小板体积/血小板计数比是早产儿迟发性败血症的预测因子:一项病例对照研究

摘要

目的:我们的目的是评估迟发性败血症 (LOS) 情况下的平均血小板体积 (MPV) 和平均血小板体积与血小板计数比 (MPR) 及其与导致 LOS 的细菌类型的关系。研究设计:在 LOS 开始时获得 MPV 和 MPR 水平,然后在早产儿的组内/组间分析中进行评估。结果:总共有 136 名早产儿入组。MPV 和 MPR 水平在 LOS 事件期间较高 ( P  < 0.001)。MPV 截断 >9.2 与预测 LOS 的灵敏度为 63% 和特异性为 73% 相关 ( P  < 0.001)。>0.15 的 MPR 截断值与预测革兰氏阴性 LOS 的灵敏度为 88% 和特异性为 63% 相关(P < 0.001)。结论:升高的 MPV 值和 MPR 比率可能有助于评估 LOS。

更新日期:2022-04-19
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