Introduction

Radiofrequency Echographic Multi-Spectrometry (REMS) is a novel ultrasound-based technique that has shown good reliability in the assessment of BMD in women affected by post-menopausal osteoporosis. Data on special populations with secondary osteoporosis are needed.

Objectives

The aim of this study was to compare the performance of the REMS BMD assessment with DXA in a cohort of kidney transplant recipients (KTR).

Methods

Consecutive patients referring to our KTR clinic were enrolled. All subjects fulfilled the following inclusion criteria: Caucasian population, both genders, age between 40 and 80 years, BMI < 40kg/m2. The enrolled patients underwent a lumbar spine (LS) and femoral neck (FN) examination with DXA and REMS. Differences in DXA vs REMS T-scores were analyzed through Student's t test for independent samples, correlations were tested though Pearson's correlation. Differences in prevalence were tested trough Chi-squared test. Written informed consent was obtained from all participants (protocol 1483CESC).

Results

40 patients were enrolled (table 1). At the LS, BMD was significantly lower when assessed through REMS. The correlation between the T-scores obtained with DXA and REMS are depicted in figure 1. When adopting the worst site, the prevalence of subjects with T-score <-2.5 was 40.5% with DXA and 37.8% with REMS (p=NS) and of subjects with T-score <-1 was 89% with DXA and 97.5% with REMS (p=0.003).

Conclusions

These results showed a good reliability of the REMS technology with respect to DXA in the classification of KTR patients as having low bone mass and/or osteoporosis. Furthermore, REMS might be more sensitive than DXA in the detection of early bone impairment and in the classification of KTR patients with low bone mass.

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中文翻译：

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射频回波多光谱 (REMS) 技术和 DXA 用于肾移植受者的 BMD 评估

介绍

射频回波多谱仪 (REMS) 是一种基于超声的新型技术，在评估绝经后骨质疏松症女性的 BMD 时表现出良好的可靠性。需要关于继发性骨质疏松症特殊人群的数据。

目标

本研究的目的是在一组肾移植受者 (KTR) 中比较 REMS BMD 评估与 DXA 的表现。

方法

参考我们的 KTR 诊所的连续患者被纳入。所有受试者均符合以下纳入标准：白种人，男女，年龄在 40 至 80 岁之间，BMI < 40kg/m2。入组患者接受了 DXA 和 REMS 的腰椎 (LS) 和股骨颈 (FN) 检查。通过独立样本的学生 t 检验分析 DXA 与 REMS T 分数的差异，通过 Pearson 相关性检验相关性。通过卡方检验测试患病率的差异。所有参与者都获得了书面知情同意书（协议 1483CESC）。

结果

40 名患者入组（表 1）。在 LS，通过 REMS 评估时，BMD 显着降低。DXA 和 REMS 获得的 T 分数之间的相关性如图 1 所示。当采用最差位点时，T 分数 <-2.5 的受试者的患病率分别为 DXA 的 40.5% 和 REMS 的 37.8% (p=NS) T 分数 <-1 的受试者中，DXA 为 89%，REMS 为 97.5%（p=0.003）。

结论

这些结果表明，REMS 技术在将 KTR 患者分类为低骨量和/或骨质疏松症时具有良好的可靠性。此外，REMS 在早期骨损伤的检测和低骨量 KTR 患者的分类中可能比 DXA 更敏感。

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