Introduction

Data on the relationship between peritoneal dialysis (PD), BMD and aortic calcifications (AOC) are lacking.

Objectives

to study the relationship between the degree of AOC and DXA and Radiofrequency Echographic Multi-Spectrometry (REMS) acquisitions.

Methods

Consecutive patients referring to the PD our clinic were enrolled. Lumbar spine (LS) and proximal femur REMS scans were performed, and LS (anteroposterior and laterolateral) and proximal femur DXA scans were performed as well. The degree of AOC was assessed through the semiquantitative score described by Kauppila et al and applied to the laterolateral LS DXA scans. To test for correlations between different variables, we used the Pearson's correlation for continuous variables and Spearman's rho for discrete variables. Multiple regression analysis was performed to adjust for age and body mass index (BMI) the correlation between BMD and the CKD duration. Written informed consent was obtained from all participants (protocol 1483CESC).

Results

41 total patients were enrolled (table 1). We found a statistically significant positive correlation of moderate strength between the total calcification score and the difference between the DXA AP T-score and the DXA LL T-score at the LS (p< 0.01, Spearman's rho = 0.402), figure 1. After adjustment for confounders, we found a significant negative between the LS and femoral neck BMD measured through REMS and CKD duration (table 2). The same correlation was not significant then BMD was assessed with DXA.

Conclusions

Our study confirmed that the overestimation of DXA BMD assessed with the anteroposterior scan is indeed influenced by AOC. Furthermore, our data suggest that REMS might be an interesting tool for the investigation of bone changes in CKD. Figure 1: scatter plot reporting the relationship between the difference between the AP and LL T-scores and the aortic calcifications score.

中文翻译：

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主动脉钙化与 DXA 和射频回波多光谱 (REMS) 采集之间的关系

介绍

缺乏关于腹膜透析 (PD)、BMD 和主动脉钙化 (AOC) 之间关系的数据。

目标

研究 AOC 和 DXA 的程度与射频回波多光谱 (REMS) 采集之间的关系。

方法

连续患者指的是我们诊所的 PD。进行了腰椎 (LS) 和股骨近端 REMS 扫描，并且还进行了 LS（前后和外侧）和股骨近端 DXA 扫描。AOC 的程度通过 Kauppila 等人描述的半定量评分进行评估，并应用于外侧 LS DXA 扫描。为了测试不同变量之间的相关性，我们对连续变量使用 Pearson 相关性，对离散变量使用 Spearman rho。进行多元回归分析以调整年龄和体重指数（BMI）与 BMD 和 CKD 持续时间之间的相关性。所有参与者都获得了书面知情同意书（协议 1483CESC）。

结果

共招募了 41 名患者（表 1）。我们发现总钙化评分与 DXA AP T 评分和 LS 处 DXA LL T 评分之间的差异之间存在统计学上显着的正相关性（p < 0.01，Spearman 的 rho = 0.402），图 1。调整混杂因素后，我们发现通过 REMS 和 CKD 持续时间测量的 LS 和股骨颈 BMD 之间存在显着负值（表 2）。相同的相关性不显着，然后用 DXA 评估 BMD。

结论

我们的研究证实，通过前后扫描评估的 DXA BMD 的高估确实受到 AOC 的影响。此外，我们的数据表明，REMS 可能是研究 CKD 骨骼变化的有趣工具。图 1：散点图报告 AP 和 LL T 分数之间的差异与主动脉钙化分数之间的关系。