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Factors Affecting ICU Stay and Length of Stay in the ICU in Patients with HELLP Syndrome in a Tertiary Referral Hospital
International Journal of Hypertension ( IF 1.9 ) Pub Date : 2022-04-18 , DOI: 10.1155/2022/3366879
Elif Ağaçayak 1 , Rezan Bugday 1 , Nurullah Peker 1 , Ugur Deger 2 , Gönül Ölmez Kavak 3 , Mehmet Siddik Evsen 1 , Talip Gul 1
Affiliation  

Objective. The study aimed to compare patients with HELLP syndrome who require intensive care and who do not require intensive care and evaluate the factors affecting the length of stay in the intensive care unit. Methods. Patients were divided into two groups as follows: requiring intensive care (group 1) and not requiring intensive care (group 2). The data of both groups were compared in terms of demographic characteristics, transfusion amounts, length of stay in the intensive care unit, maternal complications, and mortality. Results. 14032 births in a tertiary center between 2011 and 2018 were evaluated in this study. During the study period, 342 patients were diagnosed with HELLP, and 32 (9.4%) of these were followed up in the intensive care unit. The length of stay in the intensive care unit was determined as 8.1 (7.2) days on average. Fresh frozen plasma, erythrocyte suspension, apheresis, and random thrombocyte transfusion were observed to be significantly more in group 1 patients. In the regression analysis, the most effective factor was found to be erythrocyte suspension and the length of stay in the intensive care unit was significantly longer in patients who had erythrocyte suspension transfusion. The receiver operating characteristic curve showed that the area under the curve value for erythrocyte transfusion was 70.6%. When the cutoff value of erythrocyte suspension was 450 (95% CI: 365–681) ml, the sensitivity was 43.8% and the specificity was 91.6%. Conclusion. We think that physicians should be careful that maternal morbidity and mortality may increase as the need for erythrocyte suspension transfusion increases in patients with HELLP syndrome. Minimum transfusion to hemodynamically stable patients can be more suitable in terms of morbidity and mortality in managing patients with HELLP syndrome requiring erythrocyte suspension transfusion. Precautions and measures should be taken in this regard.

中文翻译:

三级转诊医院HELLP综合征患者ICU住院时间和ICU住院时间的影响因素

客观。该研究旨在比较需要重症监护和不需要重症监护的 HE​​LLP 综合征患者,并评估影响重症监护病房住院时间的因素。方法。患者分为以下两组:需要重症监护(第 1 组)和不需要重症监护(第 2 组)。比较两组数据的人口学特征、输血量、重症监护病房住院时间、产妇并发症和死亡率。结果. 本研究评估了 2011 年至 2018 年间三级中心的 14032 名新生儿。在研究期间,342 名患者被诊断出患有 HELLP,其中 32 名(9.4%)在重症监护病房进行了随访。重症监护病房的平均住院时间确定为 8.1 (7.2) 天。在第 1 组患者中观察到新鲜冰冻血浆、红细胞悬液、单采术和随机输注血小板明显更多。在回归分析中,发现最有效的因素是红细胞悬液,输注红细胞悬液的患者在重症监护病房的停留时间明显更长。受试者工作特征曲线显示红细胞输注曲线下面积为70.6%。结论。我们认为医生应该小心,随着 HELLP 综合征患者对红细胞悬液输注需求的增加,产妇的发病率和死亡率可能会增加。在管理需要红细胞悬液输注的 HELLP 综合征患者的发病率和死亡率方面,对血流动力学稳定的患者进行最少输血可能更合适。在这方面应采取预防措施和措施。
更新日期:2022-04-18
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