Children are exposed to many trace elements throughout their development. Given their ubiquity and potential to have effects on children's neurodevelopment, these exposures are a public health concern. This study sought to identify trace element mixture-associated deficits in learning behavior using operant testing in a prospective cohort. We included 322 participants aged 6-7 years recruited in Mexico City with complete data on prenatal trace elements measurements (third trimester blood lead and manganese levels, and & urine cadmium and arsenic levels), demographic covariates, and the Incremental Repeated Acquisition (IRA), an associative learning task. Weighted quantile sum (WQS) regression models were used to estimate the joint association of the mixture of all four trace elements and IRA performance. Performance was adversely impacted by the mixture, with different elements relating to different aspects of task performance suggesting that prenatal exposure to trace element mixtures yields a broad dysregulation of learning behavior.

中文翻译：

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产前微量元素混合物与幼儿行为习得任务的学习缺陷有关。


儿童在整个发育过程中都会接触到许多微量元素。鉴于它们的普遍存在以及对儿童神经发育产生影响的潜力，这些接触是一个公共健康问题。本研究试图通过前瞻性队列中的操作测试来识别与微量元素混合物相关的学习行为缺陷。我们纳入了在墨西哥城招募的 322 名 6-7 岁参与者，他们提供了产前微量元素测量（妊娠晚期血铅和锰水平，以及尿镉和砷水平）、人口统计协变量以及增量重复采集 (IRA) 的完整数据，一项联想学习任务。加权分位数和 (WQS) 回归模型用于估计所有四种微量元素的混合物与 IRA 性能的联合关联。混合物对表现产生不利影响，不同的元素与任务表现的不同方面相关，这表明产前接触微量元素混合物会导致学习行为的广泛失调。