Butyrate Drives Metabolic Rewiring and Epigenetic Reprogramming in Human Colon Cancer Cells,Molecular Nutrition & Food Research

当前位置： X-MOL 学术 › Mol. Nutr. Food Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Butyrate Drives Metabolic Rewiring and Epigenetic Reprogramming in Human Colon Cancer Cells
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-04-15 , DOI: 10.1002/mnfr.202200028
Lujing Wang _{1,

2} , Ahmad Abdel Fat Shannar _{1,

2} , Renyi Wu ₁ , Pochung Chou _{1,

2} , Md Shahid Sarwar ₁ , Hsiao-Chen Kuo _{1,

2} , Rebecca Mary Peter _{1,

2} , Yujue Wang _{3,

4} , Xiaoyang Su _{3,

4} , Ah-Ng Kong ₁

Affiliation

Butyrate (B) is a short-chain fatty acid produced by dietary fiber, known to inhibit histone deacetylases (HDACs) and possess cancer-preventive/anticancer effects. However, the role of B in metabolic rewiring, epigenomic reprogramming, transcriptomic network, NRF2 signaling, and eliciting cancer-preventive effects in colorectal cancer (CRC) HCT116 cell remains unclear.

中文翻译：

丁酸盐驱动人类结肠癌细胞的代谢重组和表观遗传重编程

丁酸 (B) 是一种由膳食纤维产生的短链脂肪酸，已知可抑制组蛋白脱乙酰酶 (HDAC) 并具有防癌/抗癌作用。然而，B 在代谢重组、表观基因组重编程、转录组网络、NRF2信号传导以及在结直肠癌 (CRC) HCT116 细胞中引发癌症预防作用中的作用仍不清楚。

更新日期：2022-04-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11