Several factors exist that limit the efficacy of lung cancer treatment. These may be tumor-specific delivery of therapeutics, airway geometry, humidity, clearance mechanisms, presence of lung diseases, and therapy against tumor cell resistance. Advancements in drug delivery using nanotechnology based multifunctional nanocarriers, have emerged as a viable method for treating lung cancer with more efficacy and fewer adverse effects. This review does a thorough and critical examination of effective nano-enabled approaches for lung cancer treatment, such as nano-assisted drug delivery systems. In addition, to therapeutic effectiveness, researchers have been working to determine several strategies to produce nanotherapeutics by adjusting the size, drug loading, transport, and retention. Personalized lung tumor therapies using sophisticated nano modalities have the potential to provide great therapeutic advantages based on individual unique genetic markers and disease profiles. Overall, this review provides comprehensive information on newer nanotechnological prospects for improving the management of apoptosis in lung cancer.

中文翻译：

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使用纳米辅助药物输送系统管理肺部疾病的细胞凋亡。

有几个因素限制了肺癌治疗的疗效。这些可能是针对肿瘤的治疗药物递送、气道几何形状、湿度、清除机制、肺部疾病的存在以及针对肿瘤细胞耐药性的治疗。使用基于纳米技术的多功能纳米载体在药物输送方面取得的进步，已成为治疗肺癌的一种可行方法，具有更高的疗效和更少的副作用。这篇综述对有效的纳米肺癌治疗方法（例如纳米辅助药物输送系统）进行了彻底而严格的检查。此外，为了提高治疗效果，研究人员一直在努力确定几种通过调整尺寸、载药量、运输和保留来生产纳米治疗药物的策略。使用复杂的纳米模式的个性化肺肿瘤疗法有可能根据个体独特的遗传标记和疾病概况提供巨大的治疗优势。总的来说，这篇综述提供了关于改善肺癌细胞凋亡管理的新纳米技术前景的综合信息。