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Active nanomotors surpass passive nanomedicines: current progress and challenges
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2022-04-13 , DOI: 10.1039/d2tb00556e
Shuqin Chen 1, 2 , Yuduo Chen 1, 2 , Mingming Fu 1, 2 , Qinghua Cao 3 , Bo Wang 3 , Wenjun Chen 1, 2 , Xing Ma 1, 2, 4
Affiliation  

Artificial nanomotors show advantages over traditional nanomedicines in biomedical applications due to their active locomotion by converting various energy sources into mechanical force in situ. Currently, nanomotors are attracting wide attention in diagnosis and therapy towards clinical applications. In this perspective, we summarize recent developments of nanomotors in biomedical applications, including targeted drug delivery, biological barrier penetration, and diagnostics and cancer treatment. The development of nanomotors in biomedicine still faces considerable challenges and practical difficulties towards clinical use, which are discussed in detail. Finally, we propose potential solutions that may help the development of nanomotors towards advanced diagnostics and therapy.

中文翻译:

主动纳米电机超越被动纳米药物:当前进展和挑战

人工纳米马达在生物医学应用中显示出优于传统纳米药物的优势,因为它们通过将各种能源原位转化为机械力来进行主动运动。目前,纳米电机在临床应用的诊断和治疗中引起了广泛的关注。从这个角度来看,我们总结了纳米电机在生物医学应用中的最新发展,包括靶向药物输送、生物屏障穿透以及诊断和癌症治疗。纳米电机在生物医学中的发展仍然面临着相当大的挑战和临床应用的实际困难,对此进行了详细讨论。最后,我们提出了可能有助于纳米电机向先进诊断和治疗方向发展的潜在解决方案。
更新日期:2022-04-13
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