Epithelial cells (tuft and goblet cells) interact with immune cells on the “inside” while secreting effector molecules into the topological “outside.” In this issue of Immunity, Zhao et al. investigate an interleukin-33 (IL-33) secretion mechanism in goblet cells dependent on O-GlcNAcylation and gasdermin pores facilitating worm expulsion.

中文翻译：

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驱除蠕虫！Harry Helminth 和警报杯

上皮细胞（簇状细胞和杯状细胞）在“内部”与免疫细胞相互作用，同时将效应分子分泌到拓扑“外部”。在本期Immunity中，Zhao 等人。研究杯状细胞中白细胞介素 33 (IL-33) 分泌机制依赖于 O-GlcNAcylation 和促进蠕虫排出的 gasdermin 孔。