The impact of intestinal fungi on host physiology and their mechanisms of interaction are incompletely understood. In a recent issue of Cell, Leonardi et al. (2022) showed that mucosal fungi induce intestinal Th17 cells to produce IL-22 and IL-17A. IL-22 acts on the gut epithelium to protect barrier integrity, whereas IL-17 acts on IL-17RA⁺ neurons to enhance sociability.

中文翻译：

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真菌在肠道中打了一拳

肠道真菌对宿主生理的影响及其相互作用机制尚不完全清楚。在最近一期的Cell中，Leonardi 等人。(2022) 表明粘膜真菌诱导肠道 Th17 细胞产生 IL-22 和 IL-17A。IL-22 作用于肠上皮以保护屏障完整性，而 IL-17 作用于 IL-17RA ⁺神经元以增强社交能力。