ABSTRACT

Subjective cognitive decline (SCD) is a risk factor for dementia that may occur at higher rates in people with HIV (PWH). Prospective memory (PM) is an aspect of cognition that may help us better understand how SCD impacts daily life. Paricipants were 62 PWH aged ≥ 50 years and 33 seronegative individuals. SCD was operationalized as normatively elevated cognitive symptoms on standardized questionnaires, but with normatively unimpaired performance-based cognition and no current affective disorders. PM was measured with the Comprehensive Assessment of Prospective Memory (CAPM), the Cambridge Test of Prospective Memory (CAMPROMPT), and an experimental computerized time-based PM task. A logistic regression revealed that older PWH had a three-fold increased likelihood for SCD. Among the PWH, SCD was associated with more frequent PM symptoms and poorer accuracy on the time-based scale of the CAMPROMPT. These findings suggest that SCD disrupts PM in older PWH.

摘要

主观认知能力下降 (SCD) 是痴呆症的一个危险因素，在 HIV 感染者 (PWH) 中发生率可能更高。前瞻性记忆 (PM) 是认知的一个方面，可以帮助我们更好地理解 SCD 如何影响日常生活。参与者为 62 名年龄≥ 50 岁的 PWH 和 33 名血清反应阴性的个体。SCD 在标准化问卷中被定义为正常升高的认知症状，但正常情况下基于表现的认知未受损，并且没有当前的情感障碍。PM 是通过前瞻记忆综合评估 (CAPM)、剑桥前瞻记忆测试 (CAMPROMPT) 和实验性计算机化的基于时间的 PM 任务来测量的。逻辑回归显示，年长的 PWH 患 SCD 的可能性增加三倍。在 PWH 中，SCD 与更频繁的 PM 症状和 CAMPROMPT 基于时间的量表的准确性较差有关。这些发现表明，SCD 会破坏老年 PWH 中的 PM。