Human papillomavirus (HPV)-negative tumors distinguish from cancers associated with HPV infection. Due to its high rate of lymph node metastasis and difficulty in inchoate discover and diagnosis, the treatment efficacy of HPV-negative cancers is unsatisfactory. Epidemiological evidence suggests that HPV-negative tumor patients have a poor prognosis, and the mortality is higher than that of cancer patients caused by HPV infection. Evidence has demonstrated that noncoding RNAs (ncRNAs) play a crucial role in regulation of physiological and developmental processes. Therefore, dysregulated ncRNAs are involved in the occurrence of diversified diseases, including cancer. In cumulative studies, ncRNAs are concerned with pathogenetic mechanisms of HPV-negative tumors via regulating gene expression and signal transduction. It is important to decipher the functions of ncRNAs in HPV-negative cancers and identify the potential biomarkers, which will bring new treatment strategies for improving outcome of cancer therapy. In this review, we demonstrated the effects of ncRNAs via regulating the development and progression of HPV- negative tumors by directly or indirectly acting on target molecules, which provide a basis for future tumor targeted therapy by targeting ncRNAs for HPV-negative cancers.

人乳头瘤病毒 (HPV) 阴性肿瘤不同于与 HPV 感染相关的癌症。由于其淋巴结转移率高，早期发现和诊断困难，HPV阴性癌症的治疗效果并不理想。流行病学证据表明，HPV阴性肿瘤患者预后较差，死亡率高于HPV感染引起的癌症患者。有证据表明，非编码 RNA (ncRNA) 在调节生理和发育过程中起着至关重要的作用。因此，失调的 ncRNA 与包括癌症在内的多种疾病的发生有关。在累积研究中，ncRNA通过调节基因表达和信号转导与HPV阴性肿瘤的发病机制有关。解读 ncRNA 在 HPV 阴性癌症中的功能并确定潜在的生物标志物非常重要，这将为改善癌症治疗结果带来新的治疗策略。在这篇综述中，我们展示了ncRNA通过直接或间接作用于靶分子来调节HPV阴性肿瘤的发展和进展的作用，这为未来通过靶向ncRNA治疗HPV阴性癌症的肿瘤靶向治疗提供了基础。