Background/aims To evaluate the electroretinographic (ERG) changes in the early postoperative period following glaucoma filtration surgery, and its relationship with choroidal detachment (CD). Methods This retrospective observational single-centre study included 57 consecutive patients with primary open-angle glaucoma who underwent unilateral glaucoma filtration surgery. The patients were divided into two groups according to the presence or absence of CD. ERG components, including the photopic negative response (PhNR), a-wave and b-wave were compared before and after surgery using skin electrodes. Results There were 46 patients in the non-CD group and 11 in the CD group. ERG was recorded within 5.1 (2.1 to 8.1) (mean (95% CI)) days after surgery. In the non-CD group, the PhNR amplitude, PhNR/b-wave amplitude ratio and PhNR implicit time improved significantly after surgery (p=0.008, 0.002 and 0.039, respectively). In the CD group, the amplitude of the PhNR, a-wave and b-wave were significantly deteriorated after surgery (p=0.002, 0.001 and 0.001, respectively). Postoperative intraocular pressure (IOP) (p=0.031) and postoperative CD (p<0.001) were significantly associated with change in the PhNR amplitude in the univariate models. In the multivariate analysis, severe CD (stage 3) cases tended to be deteriorated more. Conclusion Even in the early postoperative period within several days, the PhNR amplitude increased with IOP lowering following filtration surgery in the absence of CD. The presence of CD may arrest the improvement of the retinal ganglion cell function. The present results enhance understanding the structural and functional recovery after glaucoma surgery and the role of postoperative CD. Data are available on reasonable request. The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.

中文翻译：

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滤过手术后伴有或不伴有脉络膜脱离的青光眼患者明视阴性反应的早期变化

背景/目的 评估青光眼滤过手术术后早期视网膜电图（ERG）的变化及其与脉络膜脱离（CD）的关系。方法 这项回顾性观察性单中心研究纳入了 57 名连续接受单侧青光眼滤过手术的原发性开角型青光眼患者。根据是否患有 CD，将患者分为两组。使用皮肤电极在手术前后比较 ERG 成分，包括明视负反应 (PhNR)、a 波和 b 波。结果非CD组46例，CD组11例。术后 5.1（2.1 至 8.1）（平均（95% CI））天内记录 ERG。在非 CD 组中，PhNR 幅度，手术后 PhNR/b 波振幅比和 PhNR 隐式时间显着改善（分别为 p=0.008、0.002 和 0.039）。在CD组中，手术后PhNR、a波和b波的幅度显着恶化（分别为p=0.002、0.001和0.001）。在单变量模型中，术后眼压 (IOP) (p=0.031) 和术后 CD (p<0.001) 与 PhNR 幅度的变化显着相关。在多变量分析中，严重 CD（3 期）病例往往恶化得更多。结论 即使在术后早期几天内，在没有 CD 的情况下，滤过手术后 PhNR 幅度也会随着 IOP 的降低而增加。CD 的存在可能会阻碍视网膜神经节细胞功能的改善。目前的结果增强了对青光眼手术后结构和功能恢复以及术后 CD 作用的理解。可根据合理要求提供数据。当前研究期间生成和/或分析的数据集可根据合理要求从相应作者处获得。