In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause of HSPC fate alterations promoting malignancy.

中文翻译：

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MDS/AML with del5q：获得性“核纤层病”？

在本期《细胞干细胞》中，Reilly 等人。提出LMNB1（编码核纤层蛋白 B1 的基因，通常在 MDS/AML 中缺失）的缺失，作为中性粒细胞核形状异常（称为获得性 Pelger-Huët 异常）的新遗传基础，也是 HSPC 命运改变促进恶性肿瘤的原因。