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c-Maf: The magic wand that turns on LSEC fate
Cell Stem Cell ( IF 19.8 ) Pub Date : 2022-04-07 , DOI: 10.1016/j.stem.2022.03.011
Anna R Smith 1 , Valerie Gouon-Evans 1
Affiliation  

In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs, and its overexpression specializes generic HUVECs into functional induced-LSECs, potentiating regenerative therapeutics.



中文翻译:

c-Maf:开启 LSEC 命运的魔杖

在本期Cell Stem Cell中,Gómez-Salinero 等人。(2022) 将 c-Maf 确定为肝脏发育、稳态和修复过程中小鼠肝窦内皮细胞 (LSEC) 命运和功能的驱动因素。类似地,c-Maf 定义了人类 LSEC,其过度表达将通用 HUVEC 特化为功能性诱导 LSEC,增强了再生疗法。

更新日期:2022-04-07
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