In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs, and its overexpression specializes generic HUVECs into functional induced-LSECs, potentiating regenerative therapeutics.

中文翻译：

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c-Maf：开启 LSEC 命运的魔杖

在本期Cell Stem Cell中，Gómez-Salinero 等人。(2022) 将 c-Maf 确定为肝脏发育、稳态和修复过程中小鼠肝窦内皮细胞 (LSEC) 命运和功能的驱动因素。类似地，c-Maf 定义了人类 LSEC，其过度表达将通用 HUVEC 特化为功能性诱导 LSEC，增强了再生疗法。