A Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite,Molecular Nutrition & Food Research

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A Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-04-08 , DOI: 10.1002/mnfr.202101043
Josep Rubert _{1,

2} , Pamela Gatto ₃ , Michael Pancher ₃ , Viktoryia Sidarovich ₃ , Claudio Curti ₄ , Pedro Mena _{5,

6} , Daniele Del Rio _{5,

6,

7} , Alessandro Quattrone ₈ , Fulvio Mattivi _{9,

10}

Affiliation

Food Quality and Design, Wageningen University & Research, Bornse Weilanden 9, Wageningen, 6708 WG, The Netherlands.
Division of Human Nutrition and Health, Wageningen University & Research, Stippeneng 4, Wageningen, 6708 WE, The Netherlands.
HTS and Validation Core Facility, Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Department of Food and Drug, University of Parma, Parco Area delle Scienze, 27/A, Parma, 43124, Italy.
Human Nutrition Unit, Department of Food and Drug, University of Parma, Medical School Building C, Via Volturno, 39, Parma, 43125, Italy.
Microbiome Research Hub, University of Parma, Parma, 43124, Italy.
School of Advanced Studies on Food and Nutrition, University of Parma, Parma, 43126, Italy.
Laboratory of Translational Genomics, Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Dept. CIBIO - Department of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, Trento, 38123, Italy.
Metabolomics Unit, Department of Food Quality and Nutrition, Fondazione Edmund Mach - FEM, Research and Innovation Centre, Via Mach 1, San Michele all'Adige, 38098, Italy.

Epidemiological evidence suggests that a reduced risk of colorectal cancer (CRC) is correlated with high consumption of fruits and vegetables, which are major sources of fiber and phytochemicals, such as flavan-3-ols. However, it remains unknown how these phytochemicals and their specific gut-related metabolites may alter cancer cell behavior.

中文翻译：

在 3D HCT116 球体上筛选天然（多）酚和肠道相关代谢物揭示了 Flavan-3-ol 代谢物对肠道健康的益处

流行病学证据表明，结直肠癌 (CRC) 风险的降低与大量食用水果和蔬菜有关，水果和蔬菜是纤维和植物化学物质（如 3-黄烷醇）的主要来源。然而，目前尚不清楚这些植物化学物质及其特定的肠道相关代谢物如何改变癌细胞的行为。

更新日期：2022-04-08

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