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Transcriptional state and function of CD8+ memory T cells is linked to past proliferation
Nature Immunology ( IF 27.7 ) Pub Date : 2022-04-07 , DOI: 10.1038/s41590-022-01169-3


A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.

中文翻译:

CD8+记忆T细胞的转录状态和功能与过去的增殖有关

一种新的长期细胞增殖基因“记录器”揭示了中央记忆 CD8+ T 细胞分裂历史的显着异质性。重要的是,过去增殖的程度与不同的转录特征和再扩张潜力有关,突出了中央记忆 T 细胞池中未被重视的分工。
更新日期:2022-04-07
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