Study Design: 

Retrospective cross-sectional study.

Objective: 

The aim was to describe existing global sagittal alignment parameters across ages and to analyze differences according to gender and pelvic incidence (PI).

Summary of Background Data: 

Variability with age has been reported. It remains unclear how gender and spinopelvic morphology could additionally influence global alignment parameters.

Materials and Methods: 

Radiographs of 2599 individuals (5–93 y) were analyzed. Translation parameters were: Sagittal Vertical Axis (SVA)-C7, SVA-C2, SVA-Center Acoustic Meatus (CAM), C7/Sacrofemoral Distance (SFD) ratio. Inclination parameters were: C7-Vertical Tilt (VT), T1-VT and T9-VT, Odontoid-Hip Axis (OD-HA), OD-CAM. Pelvic compensation parameters were: T1-Pelvic Angle (TPA), Global Tilt (GT), Spino-Sacral Angle (SSA). Global sagittal alignment (GSA) was considered among formulae. The distribution of parameters was analyzed using a Bayesian inference. Correlations with spinopelvic parameters were investigated.

Results: 

SVA-C7, SVA-C2, SVA-CAM were larger in males and high PI, and increased significantly after 50 years (Pr>0.9999). C7/SFD decreased during growth and was larger in low PI (Pr=0.951). There was no correlation with spinopelvic parameters. Age-related variations of inclination parameters were nonsignificant. T1-VT and T9-VT increased with PI and were significantly larger in high PI (Pr>0.95). C7-VT was significantly larger in low PI (Pr>0.9999). OD-HA and OD-CAM were constant and increased after 80 years. TPA and GT increased with PI (Pr>0.9999) and age after 35 years (Pr>0.9999). SSA decreased nonsignificantly after 50 years. TPA correlated with PI (ρ=0.6130) and pelvic tilt (PT) (ρ=0.8375). GT correlated with PI (ρ=0.5961) and PT (ρ=0.8996). SSA correlated with sacral slope (ρ=0.9026). GSA was larger in high PI (Pr>0.9999) and increased after 35 years (Pr>0.9999). GSA correlated with PT (ρ=0.7732).

Conclusion: 

Translation parameters increase with age, more prominently in males and high PI. Variations of inclination parameters are smaller. Pelvic compensation parameters and GSA increase with age and are closely related to PT and spinopelvic morphology.

Level of Evidence: 

Level III.

中文翻译：

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全局矢状对准参数随性别、骨盆倾斜度和年龄的变化

学习规划： 

回顾性横断面研究。

客观的： 

目的是描述跨年龄段的现有全球矢状对齐参数，并根据性别和骨盆倾斜度 (PI) 分析差异。

背景数据摘要： 

据报道，随着年龄的变化。目前尚不清楚性别和脊柱骨盆形态如何额外影响整体对齐参数。

材料和方法： 

对 2599 名个体（5-93 岁）的射线照片进行了分析。平移参数为：矢状垂直轴（SVA）-C7、SVA-C2、SVA-中心声道（CAM）、C7/骶股距离（SFD）比率。倾斜参数为：C7-垂直倾斜（VT）、T1-VT和T9-VT、齿状体-髋轴（OD-HA）、OD-CAM。骨盆补偿参数为：T1-骨盆角（TPA）、整体倾斜（GT）、脊柱骶角（SSA）。公式中考虑了全局矢状对齐（GSA）。使用贝叶斯推理分析参数的分布。研究了与脊柱骨盆参数的相关性。

结果： 

SVA-C7、SVA-C2、SVA-CAM在男性和高PI中较大，并且在50年后显着增加（Pr>0.9999）。C7/SFD 在生长过程中下降，在低 PI 时更大（Pr=0.951）。与脊柱骨盆参数没有相关性。倾斜参数与年龄相关的变化并不显着。T1-VT 和 T9-VT 随着 PI 的增加而增加，并且在高 PI 时显着增大（Pr>0.95）。C7-VT 在低 PI 时显着更大 (Pr>0.9999)。OD-HA 和 OD-CAM 保持不变，并在 80 年后有所增加。TPA 和 GT 随着 PI (Pr>0.9999) 和 35 岁后年龄 (Pr>0.9999) 的增加而增加。50 年后 SSA 没有显着下降。TPA 与 PI (ρ=0.6130) 和骨盆倾斜 (PT) (ρ=0.8375) 相关。GT 与 PI (ρ=0.5961) 和 PT (ρ=0.8996) 相关。SSA 与骶骨斜率相关 (ρ=0.9026)。高PI时GSA较大（Pr>0.9999），35年后增加（Pr>0.9999）。GSA 与 PT 相关（ρ=0.7732）。

结论： 

翻译参数随着年龄的增长而增加，在男性和高 PI 中更为明显。倾角参数的变化较小。骨盆代偿参数和GSA随着年龄的增长而增加，与PT和脊柱骨盆形态密切相关。

证据级别： 

三级。