ABSTRACT

Background and Objectives

Various bio-psychosocial mechanisms underlying the link between anxiety, depression and cardiovascular disease risk, remain unknown. We investigated the role of irrational beliefs in conjunction with anxiety and depression in the 10-year cardiovascular disease (CVD) incidence, and the effect of biochemical and socio-behavioral factors.

Design

853[453 men (45 ± 13 years) and 400 women (44 ± 18 years)] from the ATTICA study (2002–2012) and without evidence of CVD were assessed.

Methods

The Irrational Beliefs Inventory (IBI), the Zung Self-Rating-Depression-Scale (ZDRS) and the State-Trait-Anxiety-Inventory (STAI) were used for the assessments. Incidence of CVD was defined according to the International Coding Diseases (ICD)−10 criteria.

Results

Participants with high irrational beliefs and anxiety symptoms had a 138% greater risk of developing CVD during the 10-year follow-up (2.38; 95%CI 1.75, 3.23) as compared to those without anxiety. Among others, C-reactive protein, interleukin-6 and total antioxidant capacity were mediators in the tested association. Interaction of irrational beliefs and depression was not associated with the 10-year CVD in all models.

Conclusions

Inflammation and oxidative stress, partially explained the associations between irrational beliefs and anxiety in predicting CVD risk. These findings advance psychological research in the area of primary prevention of mental health and cardiovascular diseases.

中文翻译：

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与 10 年心血管疾病风险相关的非理性信念、抑郁和焦虑：ATTICA 流行病学研究

摘要

背景和目标

焦虑、抑郁和心血管疾病风险之间存在联系的各种生物心理社会机制仍然未知。我们调查了非理性信念与焦虑和抑郁在 10 年心血管疾病 (CVD) 发病率中的作用，以及生化和社会行为因素的影响。

设计

对 ATTICA 研究（2002-2012 年）中没有 CVD 证据的 853 名 [453 名男性（45 ± 13 岁）和 400 名女性（44 ± 18 岁）] 进行了评估。

方法

非理性信念量表 (IBI)、Zung 自评抑郁量表 (ZDRS) 和状态特质焦虑量表 (STAI) 用于评估。CVD 的发病率根据国际编码疾病 (ICD)-10 标准定义。

结果

与没有焦虑的参与者相比，具有高度非理性信念和焦虑症状的参与者在 10 年随访期间患 CVD 的风险高 138% (2.38; 95%CI 1.75, 3.23)。其中，C 反应蛋白、白细胞介素 6 和总抗氧化能力是测试关联中的介质。在所有模型中，非理性信念和抑郁症的相互作用与 10 年 CVD 无关。

结论

炎症和氧化应激，部分解释了非理性信念与预测 CVD 风险的焦虑之间的关联。这些发现推动了心理健康和心血管疾病初级预防领域的心理学研究。