A case of 2-year-old girl with intractable seizures underwent 18F-FDG PET and MRI for seizure focus localization. MRI demonstrated cortical thickening and blurring of the gray-white matter interface in the right postcentral gyrus with focal hypometabolism in 18F-FDG PET. The patient subsequently was enrolled in clinical trial of 18F-SynVesT-1 PET study in epilepsy; a more restricted area of reduced 18F-SynVesT-1 uptake was noted in the thickened postcentral gyrus. The surgical limits of resection were defined based on ictal semiology, electroencephalography, and imagings. The patient is seizure-free after epilepsy surgery, with histopathology of focal cortical dysplasia type IIb.

中文翻译：

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18F-SynVesT-1 PET 治疗伴有皮质增厚的 II 型局灶性皮质发育不良。

1例2岁女孩顽固性癫痫发作，接受18F-FDG PET和MRI定位癫痫病灶。MRI 显示右侧中央后回皮质增厚和灰白质界面模糊，18F-FDG PET 显示局灶性代谢减退。该患者随后参加了 18F-SynVesT-1 PET 研究癫痫的临床试验；在增厚的中央后回中发现了 18F-SynVesT-1 摄取减少的更有限的区域。切除的手术限度是根据发作症状学、脑电图和影像学确定的。该患者在癫痫手术后无癫痫发作，组织病理学为 IIb 型局灶性皮质发育不良。