OBJECTIVE We examined whether fatigue in multiple sclerosis (MS) is linked to switching processes when switching is measured by the Trail Making Test (TMT). METHOD Eighty-three participants with MS were administered a battery of standardized tests of switching, working memory, and processing speed. Ordinary least squares regression models were used to estimate the association between fatigue severity and switching above and beyond attention, working memory, and processing speed. RESULTS We found a negative association between TMT performance and fatigue severity score. When measures of processing speed and working memory were included in the model, the switching measure continued to uniquely contribute to fatigue severity. CONCLUSIONS There may be a unique relationship between fatigue and switching processes identifiable by clinical measures of switching. Future research should continue to investigate this relationship by using both behavioral and neural markers to test models of fatigue to eventually identify specific intervention targets.

中文翻译：

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多发性硬化症患者的疲劳与临床上可进行的转换测量之间的关系。


目的 当通过轨迹制作测试 (TMT) 测量切换时，我们检查了多发性硬化症 (MS) 的疲劳是否与切换过程相关。方法 对 83 名多发性硬化症参与者进行了一系列关于转换、工作记忆和处理速度的标准化测试。使用普通最小二乘回归模型来估计疲劳严重程度与注意力、工作记忆和处理速度之外的切换之间的关联。结果我们发现 TMT 表现与疲劳严重程度评分之间呈负相关。当模型中包含处理速度和工作记忆的测量值时，转换测量值继续对疲劳严重程度产生独特的影响。结论 疲劳和转换过程之间可能存在一种独特的关系，可以通过转换的临床测量来识别。未来的研究应该继续通过使用行为和神经标记来测试疲劳模型来研究这种关系，以最终确定具体的干预目标。