The insufficient energy and spatial resolutions of radionuclide imaging with conventional scintillation detectors restrict the visualization of multiple radionuclides and of microstructures in tissue. Here we report the development and performance of an imaging system equipped with a cadmium telluride diode detector that achieves an energy resolution of 1.7% at 140 keV and a spatial resolution of 250 μm. The combination of high-resolution spectra fitted to an X-ray analysis model of the emission lines of the radionuclides in a chosen energy band allowed us to accurately determine individual radiation activities from three radionuclides to simultaneously visualize thyroid tissue (via intravenously administered iodine-125), mandibular lymph nodes (via the intramuscular injection of indium-111) and parotid lymph nodes (via a subcutaneous injection of technetium-99m) in mice. Multi-radionuclide imaging may find advantageous applications in biomedical imaging.

传统闪烁探测器的放射性核素成像的能量和空间分辨率不足限制了多种放射性核素和组织微观结构的可视化。在这里，我们报告了配备有碲化镉二极管探测器的成像系统的开发和性能，该探测器在 140 keV 时的能量分辨率为 1.7%，空间分辨率为 250 μm。将高分辨率光谱与所选能带中放射性核素发射线的 X 射线分析模型相结合，使我们能够准确地确定三种放射性核素的个体辐射活动，同时可视化甲状腺组织（通过静脉注射碘 125 ), 小鼠下颌淋巴结（通过肌肉注射铟 111）和腮腺淋巴结（通过皮下注射锝 99m）。多放射性核素成像可以在生物医学成像中找到有利的应用。