Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, and malignancies. Since the discovery of DCs almost 50 years ago, our understanding of their biology in humans has increased substantially. Here, we review both antitumor and tolerogenic DC responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs (pDCs), focusing on the human setting. In addition, we review the lineage-unrestricted “mature DCs enriched in immunoregulatory molecules” (mregDC) state recently described across different human tumors.

中文翻译：

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癌症中的人类树突状细胞

树突状细胞 (DC) 是专业的抗原呈递细胞，在感染、自身免疫性疾病和恶性肿瘤期间协调先天和适应性免疫。自从近 50 年前发现 DC 以来，我们对它们在人类中的生物学的了解已经大大增加。在这里，我们回顾了癌症中的抗肿瘤和致耐受性 DC 反应，并讨论了它们的功能特化亚群对谱系特异性的贡献，包括常规 DC (cDC) 亚群 cDC1 和 cDC2、新描述的 DC3 和浆细胞样 DCs (pDCs)，重点关注关于人设。此外，我们回顾了最近在不同人类肿瘤中描述的不受谱系限制的“富含免疫调节分子的成熟 DC”（mregDC）状态。