We described behavioral studies to highlight emotional processing deficits in Alzheimer’s disease (AD). The findings suggest prominent deficit in recognizing negative emotions, pronounced effect of positive emotion on enhancing memory, and a critical role of cognitive deficits in manifesting emotional processing dysfunction in AD. We reviewed imaging studies to highlight morphometric and functional markers of hippocampal circuit dysfunction in emotional processing deficits. Despite amygdala reactivity to emotional stimuli, hippocampal dysfunction conduces to deficits in emotional memory. Finally, the reviewed studies implicating major neurotransmitter systems in anxiety and depression in AD supported altered cholinergic and noradrenergic signaling in AD emotional disorders. Overall, the studies showed altered emotions early in the course of illness and suggest the need of multimodal imaging for further investigations. Particularly, longitudinal studies with multiple behavioral paradigms translatable between preclinical and clinical models would provide data to elucidate the time course and underlying neurobiology of emotion processing dysfunction in AD.

我们描述了行为研究以突出阿尔茨海默病 (AD) 中的情绪处理缺陷。研究结果表明，在识别负面情绪方面存在显着缺陷，积极情绪对增强记忆力有显着影响，以及认知缺陷在 AD 中表现出情绪处理功能障碍的关键作用。我们回顾了影像学研究，以突出情绪处理缺陷中海马回路功能障碍的形态学和功能标志物。尽管杏仁核对情绪刺激有反应，但海马体功能障碍会导致情绪记忆缺陷。最后，涉及主要神经递质系统与 AD 焦虑和抑郁有关的回顾性研究支持 AD 情绪障碍中胆碱能和去甲肾上腺素能信号的改变。全面的，研究表明，在病程早期情绪会发生变化，并表明需要进行多模式成像以进行进一步调查。特别是，具有可在临床前和临床模型之间转换的多种行为范式的纵向研究将提供数据来阐明 AD 中情绪处理功能障碍的时间过程和潜在的神经生物学。