Study Design: 

Retrospective study with prospectively collected data.

Objective: 

The purpose of this study is to investigate the difference in fusion rate and clinical outcome of patients with local bone as filler for the graft and demineralized bone matrix (DBM) plus only the cancellous bone from local bone as a filler for cage in 1-level posterior lumbar interbody fusion (PLIF) with cage.

Summary of Background Data: 

Cancellous bone is more advantageous than cortical bone in the local bone for improving bone formation in spine fusion surgery. There are little studies on the difference in fusion rate and reduction of fusion time using only these cancellous bones.

Methods: 

Of the 40 patients who underwent 1-level PLIF using cage, 20 patients in group A used local bone and 20 patients in group B used mixture of cancellous bone extracted separately from local bone and commercially available DBM as filler for cage. Changes in fusion rate and intervertebral spacing were measured using lateral radiography, and fusion was determined as nonunion using the Brantigan-Steffee classification. The clinical outcome was evaluated.

Results: 

There was no difference in height change over time between the two groups. Regarding union grade, group B showed better union grade than group A. However, no difference in union grade change over time was observed between the 2 groups. In group B, Oswestry Disability Index (ODI), Rolland-Morris Disability Questionnaire (RMDQ), and SF-36 mental component score (MCS) significantly decreased, but there was no difference in change over time.

Conclusions: 

In 1-level PLIF for degenerative lumbar disease, better fusion rate was observed in the group that used only cancellous bone from local bone plus DBM than that in the group that used local bone; however, there was no difference in fusion grade change over time in the 2 groups.

中文翻译：

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局部松质骨+脱矿骨基质与局部骨在1级后路腰椎椎间融合中融合率和功能结果的比较

学习规划： 

使用前瞻性收集的数据进行回顾性研究。

客观的： 

本研究的目的是探讨以局部骨作为移植物填充物和脱矿骨基质 (DBM) 加上仅使用局部骨松质骨作为融合器填充物的患者在 1 级融合率和临床结果上的差异带融合器的后路腰椎椎间融合术（PLIF）。

背景数据摘要： 

松质骨在脊柱融合手术中局部骨的改善骨形成方面比皮质骨更有优势。关于仅使用这些松质骨的融合率差异和融合时间减少的研究很少。

方法： 

在使用笼进行 1 级 PLIF 的 40 名患者中，A 组 20 名患者使用局部骨，B 组 20 名患者使用从局部骨中单独提取的松质骨和市售 DBM 的混合物作为笼的填充物。使用侧位X线摄影测量融合率和椎间间距的变化，并使用Brantigan-Steffee分类将融合确定为骨不连。评估临床结果。

结果： 

两组之间的身高随时间的变化没有差异。关于结合等级，B 组显示出比 A 组更好的结合等级。然而，两组之间没有观察到结合等级随时间变化的差异。B组中，Oswestry残疾指数（ODI）、罗兰-莫里斯残疾问卷（RMDQ）和SF-36心理成分评分（MCS）显着下降，但随时间的变化没有差异。

结论： 

在退变性腰椎疾病的 1 级 PLIF 中，仅使用局部骨松质骨加 DBM 的组比使用局部骨的组观察到更好的融合率；然而，随着时间的推移，两组的融合等级变化没有差异。