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A (Fab)ulous tool to block efflux
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2022-03-31 , DOI: 10.1038/s41589-022-00999-4
Aravind Penmatsa 1
Affiliation  

The cryo-electron microscopy structure of a fluoroquinolone efflux transporter, NorA, in complex with an antibody fragment provides a new strategy whereby peptide inhibitors derived from antibody loops could be used to block antibiotic efflux in a drug-resistant superbug.

中文翻译:

一个(极好的)阻止外流的工具

氟喹诺酮外排转运蛋白 NorA 与抗体片段复合的低温电子显微镜结构提供了一种新策略,由此衍生自抗体环的肽抑制剂可用于阻断耐药性超级细菌中的抗生素外排。
更新日期:2022-03-31
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