Depression is common in persons experiencing mild cognitive impairment (MCI), with 32% (95% Cl 27, 37) overall experiencing depression. Persons with MCI who have depression have more cognitive changes compared to those without depression. To understand how we can detect depressive symptoms in persons with MCI, we undertook a systematic review to identify tools that were validated compared with a reference standard.

We searched MEDLINE, EMBASE, PsycINFO, and Cochrane from inception to April 25, 2021, and conducted a gray literature search. Title/abstract and full-text screening were completed in duplicate. Demographic information, reference standards, prevalence, and diagnostic accuracy measures were then extracted from included articles (PROSPERO CRD: CRD42016052120).

Across databases, 8,748 abstracts were generated after removing duplicates. Six hundred and sixty-five records underwent full-text screening, with six articles included for data extraction. Nine tools were identified compared to a reference standard, with multiple demonstrating a sensitivity of 100% (Brief Assessment Schedule Depression Cards, Beck Depression Inventory-II, Cornell Scale for Depression in Dementia, Zung Self-Rated Depression Scale, and the Neuropsychiatric Inventory). The second highest sensitivity reported was 89% (Patient Health Questionnaire-9). Too few studies were available for a meta-analysis.

Multiple depression detection tools have been examined amongst MCI outpatients, with several showing high sensitivity. However, this evidence is only present in single studies, with little demonstration of how differing MCI types affect accuracy. More research is needed to confirm the accuracy of these tools amongst persons with MCI. At this time, several tools could be suitable for use in cognitive clinics.

抑郁症在轻度认知障碍 (MCI) 人群中很常见，32% (95% Cl 27, 37) 的人总体经历过抑郁症。与没有抑郁症的人相比，患有抑郁症的 MCI 人有更多的认知变化。为了了解我们如何检测 MCI 患者的抑郁症状，我们进行了系统评价，以确定与参考标准相比经过验证的工具。

我们检索了 MEDLINE、EMBASE、PsycINFO 和 Cochrane 从开始到 2021 年 4 月 25 日，并进行了灰色文献检索。标题/摘要和全文筛选一式两份完成。然后从包含的文章（PROSPERO CRD：CRD42016052120）中提取人口统计信息、参考标准、患病率和诊断准确性测量值。

在删除重复项后，跨数据库生成了 8,748 份摘要。对 665 条记录进行了全文筛选，其中 6 篇文章用于数据提取。与参考标准相比，确定了九种工具，其中多种工具的敏感性为 100%（简要评估计划抑郁症卡、贝克抑郁量表-II、康奈尔痴呆症抑郁量表、Zung 自评抑郁量表和神经精神量表） . 报告的第二高敏感性为 89%（Patient Health Questionnaire-9）。可用于荟萃分析的研究太少。

已经在 MCI 门诊患者中检查了多种抑郁症检测工具，其中一些工具显示出高灵敏度。然而，这一证据仅存在于单一研究中，几乎没有证明不同的 MCI 类型如何影响准确性。需要更多的研究来确认这些工具在 MCI 患者中的准确性。目前，有几种工具可能适用于认知诊所。