Oncometabolites are pro-tumourigenic metabolites that can determine tumour aggressiveness. This study found that methylmalonic acid is upregulated in breast lung metastasis and metastatic cancer cells. Methylmalonic acid alters the gene expression profile to induce a pro-metastatic phenotype in breast and lung cancer cells.

中文翻译：

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甲基丙二酸：一种与年龄相关的代谢物，可驱动肿瘤侵袭性


致癌代谢物是促肿瘤代谢物，可以决定肿瘤的侵袭性。这项研究发现，甲基丙二酸在乳腺肺转移和转移性癌细胞中表达上调。甲基丙二酸改变基因表达谱以诱导乳腺癌和肺癌细胞的促转移表型。