Following injury, tissue autonomously initiates a complex repair process, resulting in either partial recovery or regeneration of tissue architecture and function in most organisms. Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors, cytokines and other signaling molecules under normal conditions. However, under chronic traumatic or pathological conditions, the reparative or regenerative process of most tissues in different organs can lose control to different extents, leading to random, incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function, accompanied by the development of fibrosis, scarring or even pathogenesis that could cause organ failure and death of the organism. Ample evidence suggests that the various combinatorial fibroblast growth factor (FGF) and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis. In this review, we attempt to provide a brief update on our current understanding of the roles, the underlying mechanisms and clinical application of FGFs in tissue injury repair.

中文翻译：

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成纤维细胞生长因子信号转导系统在组织损伤修复中的作用。

受伤后，组织会自主启动复杂的修复过程，导致大多数生物体的组织结构和功能部分恢复或再生。在正常条件下，由不同生长因子、细胞因子和其他信号分子启动的信号转导通路之间的相互作用层次高度协调了修复和再生过程。然而，在慢性创伤或病理条件下，不同器官的大部分组织的修复或再生过程会不同程度地失控，导致细胞和组织的重组随机、不完整甚至有缺陷，从而往往会部分恢复原有的结构和功能。 ，伴随着纤维化的发展，疤痕甚至可能导致器官衰竭和生物体死亡的发病机制。大量证据表明，除了胚胎发育和代谢稳态调节外，各种组合成纤维细胞生长因子 (FGF) 和受体信号转导系统在损伤修复和成人组织重塑中发挥着重要作用。在这篇综述中，我们试图简要介绍我们目前对 FGF 在组织损伤修复中的作用、潜在机制和临床应用的理解。