Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19,Thorax

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Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19
Thorax ( IF 9.0 ) Pub Date : 2022-07-01 , DOI: 10.1136/thoraxjnl-2021-218582
Linzy Houchen-Wolloff _{1,

2} , Krisnah Poinasamy ₃ , Kate Holmes ₄ , Maryrose Tarpey ₅ , Claire Hastie ₆ , Kelly Raihani ₆ , Natalie Rogers ₆ , Nikki Smith ₆ , Dawn Adams ₇ , Paul Burgess ₇ , Jean Clark ₇ , Clare Cranage ₇ , Mahadev Desai ₇ , Nicola Geary ₇ , Rhyan Gill ₇ , Jitendra Mangwani ₈ , Lily Staunton ₇ , Colin Berry ₉ , Charlotte E Bolton ₁₀ , Trudie Chalder ₁₁ , James Chalmers ₁₂ , Anthony De Soyza ₁₃ , Omer Elneima _{1,

2} , John Geddes ₁₄ , Simon Heller ₁₅ , Ling-Pei Ho _{16,

17} , Joseph Jacob _{18,

19} , Hamish McAuley _{1,

2} , Aarti Parmar _{1,

2} , Jennifer K Quint ₂₀ , Betty Raman ₂₁ , Matthew Rowland ₂₂ , Amisha Singapuri ₂ , Sally J Singh _{1,

2} , David Thomas ₂₃ , Mark R Toshner _{24,

25} , Louise V Wain _{2,

26} , Alex Robert Horsley ₂₇ , Michael Marks ₂₈ , Christopher E Brightling _{1,

2} , Rachael A Evans _{2,

29}

Affiliation

Respiratory Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
Research and Innovation Advocacy, Asthma & Lung UK, London, UK.
Office for Clinical Research Infrastructure (NOCRI), National Institute for Health Research, London, UK.
James Lind Alliance, University of Southampton, Southampton, UK.
Long Covid Support, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
Patient and Public Involvement Group, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
Leicester Orthopaedic Research Network, University Hospitals of Leicester NHS Trust, Leicester, UK.
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Respiratory Medicine, NIHR Nottingham Biomedical Research Centre Respiratory Theme, University of Nottingham, Nottingham, UK.
Pyschological Medicine, King's College London, London, UK.
Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
Lung Biology and Transplantation Group, Newcastle University, Newcastle upon Tyne, UK.
Department of Psychiatry, University of Oxford, Oxford, UK.
Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK.
Centre for Medical Imaging and Computing, University College London, London, UK.
Department of Respiratory Medicine, University College London, London, UK.
Respiratory Epidemiology, Occupational Medicine and Public Health, Imperial College London, London, UK.
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Department of Immunology and Inflammation, Imperial College London, London, UK.
Pulmonary Vascular Disease Unit, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, UK.
Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Respiratory Sciences, University of Leicester, Leicester, UK

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.

中文翻译：

患者和临床医生联合确定优先级，以确定有关 COVID-19 长期后遗症的 10 个关键研究问题

鉴于感染人数众多且持续发病率较高，显然需要进行研究来满足患有持续症状（长期 COVID）的 COVID-19 成年幸存者的需求。为了帮助指导资源和研究工作，我们完成了一项研究优先顺序确定流程，其中纳入了患有 COVID-19 持续症状的成年人、护理人员、临床医生和临床研究人员的观点。最终的十大研究问题在一次独立调解的研讨会上达成一致，其中包括：确定长期新冠肺炎的潜在机制、建立诊断工具、了解康复轨迹以及评估干预措施在疾病急性期和持续期的作用。

更新日期：2022-06-15

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