A bivariate genome-wide association study was conducted in 137 pairs of twins to explore the shared genetic loci between cognition and blood pressure (BP). Before SNPs imputation, rs72815554 is significantly (P < 5 × 10⁻⁸) associated with the cognition-pulse pressure (PP) phenotype, while after imputation, 4 and 9 SNPs are significantly associated with the cognition-SBP phenotype, and cognition-PP phenotype, respectively, including rs72815554. There existed SNPs with highly linkage disequilibrium (LD) of rs10998339, rs72815554, rs11665292, and rs10823231. Besides, rs10998347, rs12153038, and rs10998295 had higher RegulomeDB scores and are located in the transcription factors binding regions. Rs7574283 and rs58113664 are located in the super-enhancer regions which are expressed highly in the adrenal gland, artery, atrial tissue, brain, nerves, etc. There are 1108, 1154, 1071, and 1102 genes associated with cognition-SBP, cognition-DBP, cognition-PP, and cognition-mean arterial pressure (MAP) phenotypes at the suggestive significant association level (P < 0.05), respectively. Furthermore, 641, 630, 900, and 555 pathways are associated with cognition-SBP, cognition-DBP, cognition-PP, and cognition-MAP phenotypes at the suggestive significant association level (P < 0.05), respectively.

在 137 对双胞胎中进行了一项双变量全基因组关联研究，以探索认知和血压 (BP) 之间的共享基因位点。在 SNP 插补之前，rs72815554 显着（P < 5 × 10 ^-8) 与认知-脉压 (PP) 表型相关，而在插补后，4 个和 9 个 SNP 分别与认知-SBP 表型和认知-PP 表型显着相关，包括 rs72815554。存在rs10998339、rs72815554、rs11665292和rs10823231高度连锁不平衡(LD)的SNP。此外，rs10998347、rs12153038和rs10998295的RegulomeDB评分较高，位于转录因子结合区。rs7574283和rs58113664位于肾上腺、动脉、心房组织、脑、神经等中高表达的超增强子区域。与认知相关的基因有1108、1154、1071、1102个-SBP、认知- DBP、认知-PP和认知-平均​​动脉压（MAP）表型在暗示性显着关联水平（P < 0.05），分别。此外，641、630、900 和 555 条通路分别与认知-SBP、认知-DBP、认知-PP 和认知-MAP 表型在暗示性显着关联水平上相关（P < 0.05）。