To introduce abundant carboxyl (COOH) groups to the surface of multi-walled carbon nanotubes (MWCNTs) while maintaining the pristine structure of MWCNTs, 3,4,9,10-perylene tetracarboxylic acid (PTCA) was non-covalently grafted to the sidewalls of MWCNTs. The obtained PTCA functionalized MWCNTs (MWCNTs–PTCA) functioned as a scaffold for the further introduction of chitosan (CS) via electrostatic attractions and hydrogen-bonds. The resultant CS/MWCNTs–PTCA could be used for electrochemical chiral sensing of tryptophan (Trp) enantiomers due to the intrinsic chirality of CS and the high electrocatalytic activity of MWCNTs. Under optimized conditions, the Trp enantiomers could be effectively discriminated at the CS/MWCNTs–PTCA modified electrode by differential pulse voltammetry (DPV), demonstrating that the developed CS/MWCNTs–PTCA might be a potential candidate for the construction of electrochemical chiral sensors.

引入丰富的羧基（COOH) 基团在多壁碳纳米管 (MWCNTs) 的表面上，同时保持 MWCNTs 的原始结构，3,4,9,10-苝四羧酸 (PTCA) 非共价接枝到 MWCNTs 的侧壁。获得的 PTCA 功能化 MWCNTs (MWCNTs-PTCA) 可作为支架，通过静电引力和氢键进一步引入壳聚糖 (CS)。由于 CS 的固有手性和 MWCNT 的高电催化活性，所得 CS/MWCNTs-PTCA 可用于色氨酸 (Trp) 对映异构体的电化学手性传感。在优化条件下，可以通过差分脉冲伏安法（DPV）在 CS/MWCNTs-PTCA 修饰电极上有效区分 Trp 对映体，