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Dietary Flavonoids and Human Cognition: A Meta-Analysis
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-03-25 , DOI: 10.1002/mnfr.202100976 Nancy Cheng 1 , Lynne Bell 1 , Daniel J Lamport 1 , Claire M Williams 1
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-03-25 , DOI: 10.1002/mnfr.202100976 Nancy Cheng 1 , Lynne Bell 1 , Daniel J Lamport 1 , Claire M Williams 1
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Improving cognition is important in all age groups, from performance in school examinations to prevention of cognitive decline in later life. Dietary polyphenols, in particular flavonoids, have been examined for their benefits to cognitive outcomes. This meta-analysis evaluates the effects of dietary flavonoids on cognition across the lifespan. In January 2020 databases were searched for randomized controlled trials investigating flavonoid effects on human cognition. Eighty studies, comprising 5519 participants, were included in the final meta-analysis. The global analysis indicates dietary flavonoids induced significant benefit to cognitive performance (g = 0.148, p < 0.001), with subgroup analyses revealing that cocoa (g = 0.224, p = 0.036), ginkgo (g = 0.187, p ≤ 0.001), and berries (g = 0.149, p = 0.009) yielded the most notable improvements. Significant benefits were observed from chronic studies, in middle-aged and older adults, and with low and medium doses. The domains of long-term memory, processing speed, and mood showed sensitivity to flavonoid intervention. This meta-analysis provides evidence for the positive effects of flavonoids on cognition and highlights several moderating factors. Flavonoid-based dietary interventions therefore potentially offer a highly accessible, safe, and cost-effective treatment to help tackle the burden of cognitive decline.
中文翻译：
膳食黄酮类化合物与人类认知：荟萃分析
提高认知能力对于所有年龄段的人都很重要，从学校考试的表现到预防晚年认知能力下降。膳食多酚，特别是类黄酮，已被检验其对认知结果的益处。这项荟萃分析评估了膳食类黄酮对整个生命周期认知的影响。 2020 年 1 月，我们在数据库中搜索了调查类黄酮对人类认知影响的随机对照试验。最终荟萃分析中纳入了 80 项研究，涉及 5519 名参与者。总体分析表明，膳食黄酮类化合物对认知能力有显着益处（ g = 0.148， p < 0.001），亚组分析显示可可（ g = 0.224， p = 0.036）、银杏（ g = 0.187， p ≤ 0.001）、浆果（ g = 0.149， p = 0.009）产生了最显着的改善。从中年和老年人的长期研究中观察到低剂量和中剂量有显着的益处。长期记忆、处理速度和情绪领域对类黄酮干预表现出敏感性。这项荟萃分析为黄酮类化合物对认知的积极影响提供了证据，并强调了几个调节因素。因此，基于类黄酮的饮食干预措施有可能提供一种易于获得、安全且具有成本效益的治疗方法，以帮助解决认知能力下降的负担。
更新日期：2022-03-25
中文翻译：
膳食黄酮类化合物与人类认知：荟萃分析
提高认知能力对于所有年龄段的人都很重要，从学校考试的表现到预防晚年认知能力下降。膳食多酚，特别是类黄酮，已被检验其对认知结果的益处。这项荟萃分析评估了膳食类黄酮对整个生命周期认知的影响。 2020 年 1 月，我们在数据库中搜索了调查类黄酮对人类认知影响的随机对照试验。最终荟萃分析中纳入了 80 项研究，涉及 5519 名参与者。总体分析表明，膳食黄酮类化合物对认知能力有显着益处（ g = 0.148， p < 0.001），亚组分析显示可可（ g = 0.224， p = 0.036）、银杏（ g = 0.187， p ≤ 0.001）、浆果（ g = 0.149， p = 0.009）产生了最显着的改善。从中年和老年人的长期研究中观察到低剂量和中剂量有显着的益处。长期记忆、处理速度和情绪领域对类黄酮干预表现出敏感性。这项荟萃分析为黄酮类化合物对认知的积极影响提供了证据，并强调了几个调节因素。因此，基于类黄酮的饮食干预措施有可能提供一种易于获得、安全且具有成本效益的治疗方法，以帮助解决认知能力下降的负担。
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