Abstract

This study sought to evaluate the physical and antimicrobial properties of a thermopolymerizable acrylic resin (PMMA) modified with metallic methacrylate monomers -zirconia (ZM), tin (TM), and di-n-butyl (DNTMB) methacrylates. Color stability was evaluated before and after immersion of samples in a staining solution by a digital spectrophotometer. The mechanical brushing test was evaluated by the roughness test. The flexural strength test used a mechanical testing machine. Human keratinocytes were used to assess cell viability and the biofilm formation assay was carried out for 5 days, in a microcosms model after one year of specimen storage. For statistical analysis, the method chosen was based on adherence to the normal distribution model and equality of variances (p < 0.05). The addition of DNTMB to PMMA promoted great antimicrobial action, acceptable cytocompatibility, without hampering the physical-mechanical properties of the commercial material. Therefore, the modified PMMA proved to be a promisor alternative to conventional resins.

This study sought to evaluate the physical and antimicrobial properties of a thermopolymerizable acrylic resin (PMMA) modified with metallic methacrylate monomers -zirconia (ZM), tin (TM), and di-n-butyldimethacrylate-tin (DNTMB) methacrylates. Color stability was evaluated before and after immersion of samples in a staining solution using a digital spectrophotometer. The mechanical brushing test was evaluated by the roughness test. The flexural strength test used a mechanical testing machine. Human keratinocytes were used to assess cell viability and the biofilm formation assay was carried out for 5 days in a microcosm model after one year of specimen storage. For statistical analysis, the method chosen was based on adherence to the normal distribution model and equality of variances (p < 0.05). The addition of DNTMB to PMMA promoted great antimicrobial action, acceptable cytocompatibility, without hampering the physical-mechanical properties of the commercial material. Therefore, the modified PMMA proved to be a promising alternative to conventional denture base resins for dental use.

摘要

本研究旨在评估用金属甲基丙烯酸酯单体 - 氧化锆 (ZM)、锡 (TM) 和甲基丙烯酸二正丁酯 (DNTMB) 改性的可热聚合丙烯酸树脂 (PMMA) 的物理和抗菌性能。通过数字分光光度计在将样品浸入染色溶液之前和之后评估颜色稳定性。通过粗糙度测试评价机械刷涂测试。抗弯强度试验使用机械试验机。人类角质形成细胞用于评估细胞活力，生物膜形成试验在标本储存一年后的缩影模型中进行了 5 天。对于统计分析，所选择的方法是基于对正态分布模型的遵守和方差相等（p < 0.05)。在 PMMA 中添加 DNTMB 可促进良好的抗菌作用、可接受的细胞相容性，而不会妨碍商业材料的物理机械性能。因此，改性 PMMA 被证明是传统树脂的有希望的替代品。

本研究旨在评估用金属甲基丙烯酸酯单体 - 氧化锆 (ZM)、锡 (TM) 和二甲基丙烯酸二正丁酯 - 甲基丙烯酸锡 (DNTMB) 改性的可热聚合丙烯酸树脂 (PMMA) 的物理和抗菌性能。使用数字分光光度计在将样品浸入染色溶液之前和之后评估颜色稳定性。通过粗糙度测试评价机械刷涂测试。抗弯强度试验使用机械试验机。人类角质形成细胞用于评估细胞活力，并在标本储存一年后在缩影模型中进行 5 天的生物膜形成测定。对于统计分析，所选择的方法是基于对正态分布模型的遵守和方差相等（p < 0.05)。在 PMMA 中添加 DNTMB 可促进良好的抗菌作用、可接受的细胞相容性，而不会妨碍商业材料的物理机械性能。因此，改性 PMMA 被证明是牙科用传统义齿基托树脂的有希望的替代品。