Disinhibited behaviors in dementia are associated with multiple negative outcomes. However, effective interventions are under-researched. This systematic review aims to provide an overview of intervention studies that report outcome measures of disinhibited behaviors in dementia.

Systematic searches of the databases MEDLINE, EMBASE, and PsychINFO, Social Work Abstracts and Cochrane Central Register of Controlled Trial databases were conducted for publications published between 2002 and March 2020. We included hand-searched reviews, original articles, case reports, cohort studies, and randomized controlled trials (RCTs). All studies were rated for research quality. Statistical and clinical significance were considered for individual studies. Effect sizes were included where provided or calculated where possible. Mean effect sizes were calculated for RCTs only.

The systematic review included studies involving people living with dementia.

The Neuropsychiatric Inventory disinhibition subscale was used most often.

Nine pharmacological and 21 nonpharmacological intervention studies utilized different theoretical/clinical approaches. These included pain management, antidepressants, models of care, education and/or training, music-based approaches, and physical activity. The quality of research in RCTs was strong with a greater effect size in nonpharmacological compared to pharmacological approaches (mean Cohen’s d = 0.49 and 0.27, respectively). Disinhibition was a secondary outcome in all studies.

Pharmacological (including pain management and antidepressants) and, more so, nonpharmacological (models of care, education/training, physical activity, and music) approaches were effective in reducing disinhibition.

痴呆症中的去抑制行为与多种负面结果相关。然而，有效的干预措施尚未得到充分研究。本系统综述旨在概述干预研究，这些研究报告了痴呆症去抑制行为的结果测量。

对 MEDLINE、EMBASE 和 PsychINFO 数据库、社会工作文摘和 Cochrane 对照试验中央注册数据库对 2002 年至 2020 年 3 月期间发表的出版物进行了系统检索。我们包括手工检索的评论、原始文章、病例报告、队列研究、和随机对照试验（RCT）。所有研究均按研究质量进行评级。个别研究考虑了统计和临床意义。如果可能提供或计算，则包括效应大小。仅计算随机对照试验的平均效应大小。

系统评价包括涉及痴呆症患者的研究。

最常使用的是神经精神量表去抑制量表。

9 项药物干预研究和 21 项非药物干预研究采用了不同的理论/临床方法。其中包括疼痛管理、抗抑郁药、护理模式、教育和/或培训、基于音乐的方法和体育活动。随机对照试验的研究质量很高，与药物方法相比，非药物方法的效应量更大（平均 Cohen's d分别 = 0.49 和 0.27）。去抑制是所有研究的次要结果。

药理学（包括疼痛管理和抗抑郁药）以及非药理学（护理模式、教育/培训、体力活动和音乐）方法可以有效减少抑制解除。