Polypharmacy and frailty are correlated in Persons Living with HIV (PLWH) in the United States, but little is known about their correlation in resource-limited settings. Our cross-section study evaluated the correlation between polypharmacy and frailty among Thai 324 virally suppressed PLWH and 132 uninfected patients aged ≥50 between March 2016 and April 2017. The primary predictor was the number of patient-reported non-antiretroviral therapy (ART) medications. The outcome was having additional domain of the five Fried frailty phenotype domains (0 = normal, 1–2 = prefrail, >3 = frail). Most participants were male (63% PLWH, 67% uninfected) with few comorbidities (1.4 PLWH, 0.9 uninfected) and small median number of non-ART medications (2 PLWH, 1 uninfected). Frailty was uncommon (8.6% PLWH, 3.8% uninfected). Each additional non-ART medication correlated with 6% increased likelihood of having additional frailty domain among PLWH (95% CI: 0.002–0.11, p = .04) but not statistically significant among the uninfected. The association between polypharmacy and frailty is more pronounced in Thai PLWH than in participants without HIV. Further study is warranted to confirm this association in other resource-limited settings and explore potential deprescribing practices.

中文翻译：

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泰国艾滋病病毒感染者的多重用药与虚弱之间的相关性

在美国的 HIV 感染者 (PLWH) 中，多重用药和虚弱相关，但在资源有限的环境中它们的相关性知之甚少。我们的横断面研究评估了 2016 年 3 月至 2017 年 4 月期间泰国 324 名病毒抑制 PLWH 和 132 名 50 岁以上未感染患者的多药治疗与虚弱之间的相关性。主要预测因素是患者报告的非抗逆转录病毒治疗 (ART) 药物的数量. 结果是具有五个 Fried 虚弱表型域的附加域（0 = 正常，1-2 = 衰弱前，>3 = 衰弱）。大多数参与者是男性（63% PLWH，67% 未感染），合并症很少（1.4 PLWH，0.9 未感染）和非抗逆转录病毒药物的中位数较少（2 PLWH，1 未感染）。虚弱并不常见（8.6% PLWH，3.8% 未感染）。p  = .04），但在未感染者中没有统计学意义。与未感染 HIV 的参与者相比，泰国 PLWH 的多重用药与虚弱之间的关联更为明显。有必要进行进一步的研究以确认在其他资源有限的环境中的这种关联，并探索潜在的解药做法。