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Nickel/Copper-Cocatalyzed Asymmetric Benzylation of Aldimine Esters for the Enantioselective Synthesis of α-Quaternary Amino Acids
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-03-23 , DOI: 10.1002/anie.202203448
Youbin Peng 1 , Chongyu Han 1 , Yicong Luo 1 , Guanlin Li 1 , Xiaohong Huo 1 , Wanbin Zhang 1, 2
Affiliation  

The first Ni/Cu cocatalyzed asymmetric benzylation of aldimine esters has been developed. DFT calculations revealed that the strong electrophilicity of the η3-benzylnickel intermediate enabled the reaction to proceed smoothly under base-free conditions. The method was applied to the synthesis of BIRT-377 analogues, the key intermediate of PD154075 and CI-988.

中文翻译:

镍/铜催化醛亚胺酯的不对称苄基化用于对映选择性合成 α-季铵盐

已经开发了第一个 Ni/Cu 共催化的醛亚胺酯的不对称苄基化。DFT计算表明,η 3 -苄基镍中间体的强亲电性使反应在无碱条件下顺利进行。该方法应用于PD154075和CI-988的关键中间体BIRT-377类似物的合成。
更新日期:2022-03-23
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