Targeted protein degraders (TPDs) are emerging classes of therapeutics that have the potential to address difficult drug targets in new ways. In 2021, experts convened to discuss challenges in TPD safety evaluation, and supported supplementing individual efforts to address these challenges with collective development of novel decision frameworks, tools and a shared evidence base.

中文翻译：

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靶向蛋白质降解剂：呼吁采取集体行动推进安全评估

靶向蛋白降解剂 (TPD) 是新兴的一类疗法，有可能以新的方式解决困难的药物靶点。2021 年，专家们召开会议讨论 TPD 安全评估中的挑战，并支持通过集体开发新的决策框架、工具和共享证据库来补充个人应对这些挑战的努力。