Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium,Journal of Natural Medicines

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Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2022-03-22 , DOI: 10.1007/s11418-022-01613-6
Ai Ogasawara ₁ , Ryo Noguchi ₁ , Takuya Shigi ₁ , Alfarius Eko Nugroho ₁ , Yusuke Hirasawa ₁ , Toshio Kaneda ₁ , Takahiro Tougan ₂ , Toshihiro Horii ₃ , A Hamid A Hadi ₄ , Hiroshi Morita ₁

Affiliation

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F (1–6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.

Graphical abstract

中文翻译：

Caloforines A-G，来自 Calophyllum scriblitifolium 树皮的香豆素

以生物活性为导向分离Calophyllum scriblitifolium树皮的甲醇提取物，分离出五种新的吡喃香豆素，caloforines A-E ( 1-5 )和两种新的香豆素，caloforines F 和 G ( 6和7 )。它们的结构通过 1D 和 2D NMR 光谱进行了阐明，并通过 CD 光谱和 DFT 计算相结合来研究它们的绝对构型。Caloforines A-F ( 1-6 )对恶性疟原虫3D7株显示出中等的抗疟活性。

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更新日期：2022-03-22

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