Abstract

Molecular imprinting technology is used for producing molecularly imprinted polymers (MIPs). These MIPs have tailor-made binding sites for target template molecules. Recently, MIPs have been employed in a wide range of analytical fields because of their high specificity and sensitivity for their target molecules (e.g., drugs, foods, and pesticides). MIPs combined with metal-organic frameworks (MOFs) can enhance accessibility to the imprinting sites, as such combination can offer many beneficial properties (e.g., mechanical strength and high specific surface area). As such, MOF-MIPs with enhanced sensing properties have been fabricated for the detection of various targets (e.g., pesticides, mycotoxins, and proteins). In this review, the recent advances in hybrid MOF-MIP technology are discussed in association with combined strategies for their synthesis and sensing applications. The performance of diverse MOF-MIPs is also evaluated in terms of the available sensing principles (e.g., electrochemical and fluorescent sensing). The constructed MOF-MIP-based sensors are found to have good performance toward various types of targets (e.g., high sensitivity and selectivity). At last, the present challenges in the MOF-MIP-based sensing applications are discussed along with the future prospects for this research field.

摘要

分子印迹技术用于生产分子印迹聚合物 (MIP)。这些 MIP 具有针对目标模板分子的定制结合位点。最近，MIPs 因其对目标分子（如药物、食品和农药）的高度特异性和敏感性而被广泛应用于分析领域。MIP 与金属有机框架 (MOF) 相结合可以提高印迹位点的可及性，因为这种组合可以提供许多有益的特性（例如，机械强度和高比表面积）。因此，已经制造出具有增强传感特性的 MOF-MIP，用于检测各种目标（例如，杀虫剂、霉菌毒素和蛋白质）。在这篇评论中，混合 MOF-MIP 技术的最新进展结合其合成和传感应用的组合策略进行了讨论。各种 MOF-MIP 的性能也根据可用的传感原理（例如，电化学和荧光传感）进行评估。发现构建的基于 MOF-MIP 的传感器对各种类型的目标具有良好的性能（例如，高灵敏度和选择性）。最后，讨论了基于 MOF-MIP 的传感应用目前面临的挑战以及该研究领域的未来前景。发现构建的基于 MOF-MIP 的传感器对各种类型的目标具有良好的性能（例如，高灵敏度和选择性）。最后，讨论了基于 MOF-MIP 的传感应用目前面临的挑战以及该研究领域的未来前景。发现构建的基于 MOF-MIP 的传感器对各种类型的目标具有良好的性能（例如，高灵敏度和选择性）。最后，讨论了基于 MOF-MIP 的传感应用目前面临的挑战以及该研究领域的未来前景。