Normal growth pattern variations [i.e., constitutional advancement and constitutional delay of growth and puberty (CAGP and CDGP)] are the mirror image of each other and are associated with early puberty (EP) and delayed puberty (DP), respectively. Differences between CAGP and CDGP relate not only to auxological characteristics (height, weight) but also to insulin-like growth factor-1 (IGF-1). IGF-1 levels in CAGP are above average whereas in CDGP they are below average, suggesting a role for IGF-1 in the induction of these growth patterns. Herein, we provide data suggesting that early activation of the growth hormone (GH)/IGF-1 axis induces the growth pattern of CAGP. Moreover, we suggest that IGF-1 is a decisive factor for the release of the gonadotropin-releasing hormone (GnRH) inhibition brake that occurs in prepuberty. It is therefore crucial for puberty onset.

正常的生长模式变化[即生长和青春期的体质提前和体质延迟（CAGP 和 CDGP）] 是彼此的镜像，分别与青春期提前 (EP) 和青春期延迟 (DP) 相关。CAGP 和 CDGP 之间的差异不仅与生长特征（身高、体重）有关，还与胰岛素样生长因子-1 (IGF-1) 有关。CAGP 中的 IGF-1 水平高于平均水平，而 CDGP 中的水平低于平均水平，这表明 IGF-1 在诱导这些生长模式中的作用。在这里，我们提供的数据表明生长激素 (GH)/IGF-1 轴的早期激活诱导 CAGP 的生长模式。此外，我们认为 IGF-1 是青春期前促性腺激素释放激素 (GnRH) 抑制制动释放的决定性因素。