Development and Evaluation of Targeted Optical Imaging Probes for Image-Guided Surgery in Head and Neck Cancer,Advanced Therapeutics

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Development and Evaluation of Targeted Optical Imaging Probes for Image-Guided Surgery in Head and Neck Cancer
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2022-03-21 , DOI: 10.1002/adtp.202100196
Yue Wu ₁ , Haiwei Wu ₁ , Xiaoya Lu ₁ , Yi Chen ₁ , Xue Zhang ₂ , Jiandong Ju ₁ , Dongsheng Zhang ₁ , Baocun Zhu ₂ , Shengyun Huang ₁

Affiliation

Head and neck cancer is the 7th most common cancer in the world and the primary treatment is surgical resection. Optical probes have shown great potential for application in image-guided surgery to delineate tumor margins more accurately. Special biomarkers that are aberrant in tumors are considered in tumor-targeting strategies. Targeted fluorescent probes can enable accurate visualization of tumor margins with appropriate targeting strategies, thereby providing better sensitivity and specificity. In this review, the preclinical evidence on optical probes that have been developed with specific targeting strategies is summarized and challenges in the clinical translation of novel targeted fluorescent probes are discussed.

中文翻译：

用于头颈癌图像引导手术的靶向光学成像探头的开发和评估

头颈癌是世界上第七大最常见的癌症，主要治疗方法是手术切除。光学探针在图像引导手术中显示出巨大的应用潜力，可以更准确地描绘肿瘤边缘。在肿瘤靶向策略中考虑了在肿瘤中异常的特殊生物标志物。靶向荧光探针可以通过适当的靶向策略实现肿瘤边缘的准确可视化，从而提供更好的灵敏度和特异性。在这篇综述中，总结了使用特定靶向策略开发的光学探针的临床前证据，并讨论了新型靶向荧光探针临床转化中的挑战。

更新日期：2022-03-21

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