Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are defined by their exclusive activation by MAPKs. They can be activated by classical and atypical MAPKs that have been stimulated by mitogens and various stresses. Genetic deletions of MAPKAPKs and availability of highly specific small-molecule inhibitors have continuously increased our functional understanding of these kinases. MAPKAPKs cooperate in the regulation of gene expression at the level of transcription; RNA processing, export, and stability; and protein synthesis. The diversity of stimuli for MAPK activation, the crosstalk between the different MAPKs and MAPKAPKs, and the specific substrate pattern of MAPKAPKs orchestrate immediate-early and inflammatory responses in space and time and ensure proper control of cell growth, differentiation, and cell behavior. Hence, MAPKAPKs are promising targets for cancer therapy and treatments for conditions of acute and chronic inflammation, such as cytokine storms and rheumatoid arthritis.

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MAPK 激活的蛋白激酶：仆人还是伙伴？


丝裂原激活蛋白激酶 (MAPK) 激活蛋白激酶 (MAPKAPK) 的定义是仅由 MAPK 激活。它们可以被有丝分裂原和各种应激刺激的经典和非典型 MAPK 激活。 MAPKAPK 的基因缺失和高度特异性小分子抑制剂的可用性不断增加了我们对这些激酶功能的了解。 MAPKAPKs 在转录水平上协同调节基因表达； RNA加工、输出和稳定性；和蛋白质合成。 MAPK 激活刺激的多样性、不同 MAPK 和 MAPKAPK 之间的串扰以及 MAPKAPK 的特定底物模式在空间和时间上协调早期反应和炎症反应，并确保对细胞生长、分化和细胞行为的适当控制。因此，MAPKAPK 是癌症治疗和急性和慢性炎症（例如细胞因子风暴和类风湿性关节炎）治疗的有希望的靶标。