A method connecting single-cell genomic, transcriptomic or proteomic profiles to functional cellular characteristics, especially time-varying phenotypic changes, would inform our understanding of cancer biology. We present functional single-cell sequencing (FUNseq) to address this need and describe how it might provide a unique way to unravel mechanisms that drive cancer.

中文翻译：

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功能性单细胞测序将动态表型与其基因型联系起来

将单细胞基因组、转录组或蛋白质组谱与功能细胞特征，尤其是随时间变化的表型变化联系起来的方法，将有助于我们了解癌症生物学。我们提出了功能性单细胞测序 (FUNseq) 来满足这一需求，并描述了它如何提供一种独特的方法来解开导致癌症的机制。