Beige adipocytes possess a discrete developmental origin and notable plasticity in thermogenic capacity in response to various environmental cues. But the transcriptional machinery controlling beige adipocyte development and thermogenesis remains largely unknown. By analyzing beige adipocyte-specific knockout mice, we identified a transcription factor, Forkhead Box P4 (FOXP4) that differentially governs beige adipocyte differentiation and activation. Depletion of Foxp4 in progenitor cells impaired beige cell early differentiation. However, we observed that ablation of Foxp4 in differentiated adipocytes profoundly potentiated their thermogenesis upon cold exposure. Of note, the outcome of Foxp4-deficiency on UCP1-mediated thermogenesis was confined to beige adipocytes, rather than to brown adipocytes. Taken together, we submit that FOXP4 primes beige adipocyte early differentiation, but attenuates their activation by potent transcriptional repression of the thermogenic program.

中文翻译：

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FOXP4 差异控制冷诱导的米色脂肪细胞分化和产热。

米色脂肪细胞具有离散的发育起源和显着的产热能力可塑性，以响应各种环境线索。但控制米色脂肪细胞发育和产热的转录机制在很大程度上仍然未知。通过分析米色脂肪细胞特异性基因敲除小鼠，我们确定了一种转录因子 Forkhead Box P4 (FOXP4)，它对米色脂肪细胞的分化和激活有不同的控制作用。祖细胞中 Foxp4 的消耗损害了米色细胞的早期分化。然而，我们观察到消融分化的脂肪细胞中的 Foxp4 极大地增强了它们在冷暴露时的产热。值得注意的是，Foxp4 缺陷对 UCP1 介导的产热作用的结果仅限于米色脂肪细胞，而不是棕色脂肪细胞。综合起来，