Abstract

Human health is a subject matter that requires a multifold strategy starting by understanding the molecular basis of diseases, development of diagnostic approaches, and subsequently by finding possible innovative treatments. Neurodegenerative diseases, degenerative medicine, diabetes, preeclampsia, and pharmaceutics are just a few examples to mention. Therefore, the challenge for the scientific community is to develop new and creative means for acquiring, processing and interpreting the biomolecular information involved with tissues, single cells or cells in a microenvironment, at cellular and sub-cellular resolution. Synchrotron facilities open the door for a huge number of biological and biomedical applications, where high spatial resolution and high quality information are a must. This review highlights the strong role that the Synchrotron radiation-FTIR microspectroscopy (SR-μFTIR) plays in various biomedical fields with a special focus on the above-mentioned cases.

摘要

人类健康是一个需要采取多重策略的主题，首先要了解疾病的分子基础，开发诊断方法，然后寻找可能的创新疗法。神经退行性疾病、退行性医学、糖尿病、先兆子痫和药剂学只是其中的几个例子。因此，科学界面临的挑战是开发新的、创造性的方法，以细胞和亚细胞分辨率获取、处理和解释与微环境中的组织、单细胞或细胞有关的生物分子信息。同步加速器设施为大量生物和生物医学应用打开了大门，其中高空间分辨率和高质量信息是必须的。