Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst,Organic Process Research & Development

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Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2022-03-16 , DOI: 10.1021/acs.oprd.2c00061
Sloan Ayers ₁ , Gregory L. Beutner ₁ , Wei Ding ₁ , Carolyn Higman ₁ , Charles Pathirana ₁ , Robert Wethman ₁

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Having robust and reliable methods for monitoring catalyst activation processes is an important part of ensuring the reproducibility of a catalytic reaction. For asymmetric Diels–Alder reactions, chiral oxazaborolidine or oxazaborolidinium catalysts are powerful reagents that promote these reactions in high yield and selectivity. Supported by mechanistic findings, several modern analytical methods are compared for quantitating the oxazaborolidine catalyst formation from amino alcohol and boroxine to arrive at useful monitoring methods for this important transformation.

中文翻译：

监测手性恶唑硼烷催化剂形成的可靠分析方法

拥有监测催化剂活化过程的稳健可靠的方法是确保催化反应重现性的重要部分。对于不对称 Diels-Alder 反应，手性 oxazaborolidin 或 oxazaborolidinium 催化剂是促进这些反应以高产率和选择性进行的强大试剂。在机理研究的支持下，比较了几种现代分析方法，以量化氨基醇和环硼氧杂环硼烷催化剂的形成，从而得出对这一重要转化有用的监测方法。

更新日期：2022-03-16

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