Objective: This retrospective analysis assessed regression-based reliable change (RC) of cognition in a sample of essential tremor (ET) patients who underwent unilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM-DBS).Method: Thirty patients (mean age at pre-evaluation = 70.4 ± 6.3 years) underwent neuropsychological evaluation pre- and post-unilateral VIM-DBS placement (mean time between pre and post-evaluation = 13.1 ± 4.0 months). Paired samples t-tests and RC analyses were employed.Results: No significant within-group differences were observed when cognitive scores were compared between evaluations. The vast majority of patients demonstrated stability across pre-and post-surgical evaluations (i.e. 29 out of 30); however, those with high-risk co-morbid medical conditions may be vulnerable to post-surgical cognitive decline as indicated by RC measures.Conclusions: The use of regression-based RC indices to assess individual cognitive changes between pre and post-surgical evaluations control for systematic and measurement errors that can occur over repeated evaluations, and may be able to identify cognitive changes that evade detection in traditional within-group comparisons.

中文翻译：

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特发性震颤单侧深部脑刺激后可靠的认知变化。


目的：这项回顾性分析评估了接受单侧丘脑腹侧中间核深部脑刺激 (VIM-DBS) 的特发性震颤 (ET) 患者样本中基于回归的可靠认知变化 (RC)。方法：30 名患者（预评估时的平均年龄 = 70.4 ± 6.3 岁）在单侧 VIM-DBS 放置前后接受神经心理学评估（评估前和评估后之间的平均时间 = 13.1 ± 4.0 个月）。采用配对样本 t 检验和 RC 分析。结果：比较评估之间的认知得分时，没有观察到显着的组内差异。绝大多数患者在手术前和术后评估中表现出稳定性（即 30 名患者中的 29 名）；然而，如 RC 测量所示，那些患有高风险共存疾病的人可能容易受到术后认知能力下降的影响。结论：使用基于回归的 RC 指数来评估手术前后评估控制之间的个体认知变化针对重复评估中可能发生的系统和测量误差，并且可能能够识别在传统组内比较中逃避检测的认知变化。