How blood stem cells balance fate decisions between quiescence maintenance and differentiation during recovery from cancer treatment remains poorly understood. A recent study by Umemoto et al (2022) uncovers an unexpected linkage between metabolic and epigenetic regulation of haematopoiesis, suggesting new targets in haematopoietic regeneration, with possible implications in leukaemogenesis and therapy resistance.

中文翻译：

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干细胞“驯化”以再生血液系统。

血液干细胞如何在癌症治疗恢复期间平衡静止维持和分化之间的命运决定仍然知之甚少。Umemoto 等人 (2022) 最近的一项研究揭示了造血功能的代谢和表观遗传调节之间意想不到的联系，暗示了造血再生的新目标，可能对白血病发生和治疗耐药性产生影响。